CLINICAL SCIENCE PROP1 and CTNNB1 expression in adamantinomatous craniopharyngiomas with or without b-catenin mutations
نویسندگان
چکیده
Carolina M.G. Cani, Hamilton Matushita, Luciani R. S. Carvalho, Ibere C. Soares, Luciana P. Brito, Madson Q. Almeida, Berenice B. Mendonça I Faculdade de Medicina da Universidade de São Paulo, Disciplina de Endocrinologia, Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM/42, São Paulo, SP/Brazil. II Faculdade de Medicina da Universidade de São Paulo, Departamento de Neurologia, São Paulo, SP/Brazil. III Faculdade de Medicina da Universidade de São Paulo, Divisão de Anatomia Patológica, Laboratório de Patologia Hepática/LIM14, São Paulo, SP/Brazil.
منابع مشابه
PROP1 and CTNNB1 expression in adamantinomatous craniopharyngiomas with or without β-catenin mutations
INTRODUCTION Activating mutations in exon 3 of the β-catenin gene are involved in the pathogenesis of adamantinomatous craniopharyngiomas. Recently, the interaction between β-catenin and PROP1 has been shown to be responsible for pituitary cell lineage determination. We hypothesized that dysregulated PROP1 expression could also be involved in the pathogenesis of craniopharyngiomas OBJECTIVES ...
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